Scientist F
Email: patelv[at]nirrh[dot]res[dot]in
Phone: +(91-22) 2419-2020
Department: Viral Immunopathogenesis
Research Interests
- Viral pathogenesis and genomics
- Immunology
- Vaccine design
Academic Background
| Degree | Academic institute | Year |
| BSc Life Science & Biochemistry | St. Xavier’s College, Mumbai | 1994 |
| MSc Biotechnology | D.A.V.V. Indore | 1996 |
| PhD Applied Biology | University of Mumbai | 2003 |
Professional Experience
| Post held | Institute/Organization | From | To |
| Scientist ‘E’ and Head, Dept. of Biochemistry & Virology | National Institute for Research in Reproductive Health, Parel, Mumbai. | 2018 | Present |
| Scientist ‘D’ and Head, Dept. of Biochemistry & Virology | National Institute for Research in Reproductive Health, Parel, Mumbai. | 2013 | 2018 |
| Ramalingaswami Fellow | National Institute for Research in Reproductive Health, Parel, Mumbai. | 2011 | 2016 |
| Research Fellow (Full Time Employee) | National Institutes of Health, USA | 2008 | 2011 |
| Post-Doctoral Fellow | National Institutes of Health, USA | 2003 | 2008 |
Present
| Name | Designation |
| Ms Snehal Kaginkar | PhD Student |
| Ms Harsha Palav | PhD Student |
| Ms Shilpa Bhowmick | PhD Student |
| Mr Nandan Mohite | PhD Student |
Past
| Name | Designation | From | To |
| Ms Jyoti Sutar | PhD Student | 2010 | 2021 |
| Ms Varsha Prabhu | PhD Student | 2010 | 2022 |
| Ms Sukeshani Salve | PhD Student | 2012 | 2019 |
| Mr Amitkumar Singh | PhD Student | 2013 | 2023 |
Awards & Achievements
| Name of Award | Awarding agency | Year |
| Award for Contribution to COVID-19 efforts Global Scholar Award Keystone Symposia Global Health Travel Award |
Metropolis Foundation American Society for Virology (ASV) Bill & Melinda Gates Foundation |
2022 2023 2020 |
| Board of Studies Member: Life Sciences & Biochemistry, St Xavier’s College (Autonomous), Mumbai; Molecular Biology, Mumbai University. | 2020- present | |
| Adjunct Faculty: Centre of Excellence in Immunology (CoE), ICMR-NIRRCH & BYL Nair Hospital; teaching immunology to post and undergraduate medical students. | 2022- present | |
| Visiting Faculty: Centre of Excellence in Basic Sciences, University of Mumbai, teaching basic and advanced immunology (2013 onwards). | 2014- present |
Publications
The dynamics of SARS-CoV-2 infection in unvaccinated and vaccinated populations in Mumbai, India, between 28 December 2020 and 30 August 2021.
2023
Severe acute respiratory syndrome coronavirus 2 positivity in neonates born to coronavirus disease 2019positive mothers: A retrospective data analysis.
2023
A Novel Gut Microbiome-Immune Axis influencing pathology in HCMV Infected Infants with Neonatal Cholestasis.
2023
LHX2 in germ cells control tubular organization in the developing mouse testis.
2023
Cytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report.
2023
Integrated immune monitoring of HCMV infection in pregnant women with complications and its association with adverse pregnancy outcomes.
2023
Characterization of peripheral T helper 17 (Th17) cells phenotype in postmenopausal women with estrogen insufficiency.
2023
Highly dampened HIV-specific cytolytic effector T cell responses define viremic non-progression.
2022
Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology
2022
Singh AK, Kasarpalkar N, Bhowmick S, Paradkar G, Talreja M, Shah K, Tiwari A, Palav H, Kaginkar S, Kulkarni R, Patil A, Kalsurkar V, Agrawal S, Shastri J, Dere R, Bharmal R, Mahale SD, Bhor VM, Patel V. Opposing roles for sMAdCAM and IL-15 in COVID-19 associated cellular immune pathology.
Elevated risk of COVID-19 infection among people living with HIV in Mumbai – A retrospective study.
2022
Estrogen receptor expression is modulated in human and mouse prostate epithelial cells during cancer progression
2022
Nanoparticles eluting stents for coronary intervention: Formulation, characterization and in vitro evaluation.
2022
Elevated Risk of COVID-19 Infection among People Living with HIV in Mumbai – A Retrospective Study. Re:GEN Open 2022
2022
Ketki Jawade, Priyanka Singh, Shahina Begum, Sharad Bhagat, Reshma Gaonkar, Shilpa Kerkar, Clara Aranha, Venkanna Bhanothu, Dimpu Gogoi, Karan Shah, Nupur Mukherjee, Kiran Munne, Shailesh Pande, Geetanjali Sachdeva, Smita D Mahale, Vikrant M Bhor, Dhanashree Jagtap, Vainav Patel
An Approach to Resolve Uncertainty in COVID-19 Diagnosis due to Inconclusive Results from RT-PCR Test.
2022
A retrospective analysis of COVID-19 diagnosis results obtained by rapid antigen tests and RT-PCR: Implications for disease management
2021
pH Stress Mediated Alteration in Protein Composition and Reduction in Cytotoxic Potential of Gardnerella vaginalis Membrane Vesicles.
2021
Detection of SARS-CoV-2 infection by RT-PCR test: factors influencing interpretation of results.
2021
sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 Infection.
2021
A novel ORF1a-based SARS-CoV-2 RT- PCR assay to resolve inconclusive samples.
2021
Cycle threshold values in RT‐PCR to determine dynamics of SARS‐ CoV‐2 viral load: An approach to reduce the isolation period for COVID‐19 patients.
2021
A novel ORF-1a based SARS- CoV- 2 RT-PCR assay to resolve inconclusive samples.
2021
Frequency of effector memory cells expressing integrin α4β7 is associated with TGF-β1 levels in therapy naïve HIV infected women with low CD4+ T cell count.
2021
Analysis of sequence diversity and selection pressure in HIV-1 clade C gp41 from India.
2020
Delineation of homeostatic immune signatures defining viremic non-progression in HIV-1 infection.
2020
Hepatic interferon γ and tumor necrosis factor α expression in infants with neonatal cholestasis and cytomegalovirus infection.
2020
Small double-stranded RNA with anti-HIV activity abundantly produced by Bacillus subtilis MTCC5480 isolated from fermented soybean.
2020
Vaginal siRNA delivery: overview on novel delivery approaches.
2020
Persistence of SARS-CoV-2 in the first trimester placenta leading to vertical transmission and fetal demise from an asymptomatic mother
2020
Modelling and docking of Indian SARS-CoV-2 spike protein 1 with ACE2: implications for co-morbidity and therapeutic intervention.
2020
Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8
2019
Detection of Cytomegalovirus in Liver Tissue by Polymerase Chain Reaction in Infants With Neonatal Cholestasis
2018
Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans.
2018
Optimization of Ex Vivo Murine Bone Marrow Derived Immature Dendritic Cells: A Comparative Analysis of Flask Culture Method and Mouse CD11c Positive Selection Kit Method.
2018
Dose-dependent inhibition of Gag cellular immunity by Env in SIV/HIV DNA vaccinated macaques
2015
Immunogenicity of Semliki Forest virus based self-amplifying RNAexpressing Indian HIV-1C genes in mice
2015
Foeniculum vulgare Mill: A Review of Its botany, phytochemistry, pharmacology, contemporary application and toxicology
2014
Traditional uses, phytochemistry and pharmacology of Ficus carica: A plant review
2014
DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge
2013
Patel V, Jalah R, Kulkarni V, Valentin A, Rosati M, Alicea C, Gegerfelt A von, Huang W, Guan Y, Keele B F, Bess, Jr JW, Piatak, Jr M, Lifson J D, Williams W T, Shen X, Tomaras G T, Amara R R, Robinson H L, Johnson W, Broderick K E, Sardesai NY, Venzon DJ, Hirsch VM, Felber BK, and Pavlakis GN
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques
2012
Projects Ongoing
| Project title | Funding agency | From | To |
| Immune & Microbiome Correlates of TB reactivation in PLHIV and a NHP model | Indo-U.S. Joint Program On Prevention Of Hiv/Aids And Stds Collaborative Awards (ICMR-NIH) | 2019 | 2023 |
| Developing Broadly Neutralizing Monoclonal Antibody (bnAb) Mediated Prevention and Treatment Strategy by Assessing Their Effectiveness in Neutralizing HIV‐1 Subtype C Circulating in India Across Different Regions and Distinct Risk Groups | India Alliance (DBT Welcome) Team Science Grant | 2020 | 2025 |
| An integrated approach towards characterizing the Treg reservoir in HIV-1 infection. | DST-SERB | 2023 | 2026 |
| Immune response to precautionary third dose of COVISHIELD/COVAXIN among healthy adult population: an ICMR Cohort study, India | ICMR | 2022 | 2024 |
| Studies on HIV Latency and Reactivation in Cellular Reservoirs | ICMR-NIRRCH | ||
| Host Pathogen Signatures Associated with Congenital Transmission and Pathogenesis of Human Cytomegalovirus | ICMR_NIRRCH | ||
Projects Completed
| Project title | Funding agency | From | To |
| To study the immunopathogenesis of HIV with respect to immune impairment | DBT (Ramalingaswami Fellowship) | 2011 | 2017 |
| Study of the role of CD4+ regulatory T cells (Treg) in HIV- infected immunologically discordant individuals undergoing anti-retroviral therapy (ART) | DBT (RGYI) | 2013 | 2017 |
| Intranasal Mucosal Vaccine for COVID-19 (Co-PI) | DBT-BIRAC | 2020 | 2022 |
| Evaluation of immunogenicity and protective efficacy of bivalent vaccine candidate against Shigella and Salmonella using food grade bacteria Lactococcus lactis | DST-SERB | 2018 | 2021 |