Kushaan Khambata - ICMR-NIRRCH

Scientist C

Email: khambatak@nirrch.res.in
Phone: 022-24192006
Department: Gamete Immunobiology

Research Interests

Reproductive Endocrinology
Epigenetics
Mechanisms governing male fertility and sperm quality

Academic Background

B. Sc. (Biotechnology), Jai Hind College, University of Mumbai, 2008
M. Sc. (Bioanalytical Sciences), G. N. Khalsa College, University of Mumbai, 2010
Ph. D. (Life Sciences), NIRRH, University of Mumbai, 2018

Professional Experience

Scientist	Institution	From	To
ICMR-Senior Research Fellow (SRF)	NIRRH	2017	2019
ICMR-Senior Research Fellow (SRF)	NIRRH	2012	2015
ICMR-Junior Research Fellow (JRF)	NIRRH	2010	2012

Awards & Achievements

Publications

Projects

Publications

Dopamine receptor D2 regulates genes involved in germ cell movement and sperm motility in rat test.

2024

Raut S, Khambata K, Singh D, Balasinor NH.

Biol Reprod. 2024 Feb 10;110(2):377-390.

Molecular mechanisms underlying the effects of hypo- and hyper-prolactinemia on spermatogenesis and fertility in male rats

2024

Raut S, Khambata K, Singh D, Balasinor NH

J Endocrinol Invest. 2024 Oct 3 https://doi.org/10.1007/s40618-024-02471-7

DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss.

2023

Khambata K, Begum S, Raut S, Mohan S, Irani D, Singh D, Bansal V, Patil A, Balasinor NH.

Epigenetics. 2023 Dec;18(1):2252244. doi: 10.1080/15592294.2023.2252244.PMID: 37699152

Paternal obesity induces epigenetic aberrations and gene expression changes in placenta and fetus.

2023

Deshpande-SS, Bera P, Khambata K, Balasinor NH

Mol Reprod Dev 90(2): 109-126, 2023

Immunoregulation in the testis and its implication in fertility and infections.

2021

Khambata K, Modi D, Gupta SK.

Exploration of Immunology. 1:309–324.

DNA methylation defects in spermatozoa of male partners from couples experiencing recurrent pregnancy loss.

2021

Khambata K, Raut S, Deshpande-S, Mohan S, Sonawane S, Gaonkar R, Ansari Z, Datar M, Bansal V, Patil A, Warke H, Balasinor NH.

Human Reproduction. 36(1):48-60.

Genome-wide identification of estrogen receptor binding sites reveals novel estrogen-responsive pathways in adult male germ cells.

2020

Raut S, Kumar A, Khambata K, Deshpande-S, Balasinor NH.

Biochem J 477(12): 2115-2131, 2020.

Genetically Inherited Obesity and High-Fat Diet–Induced Obesity Differentially Alter Spermatogenesis in Adult Male Rats.

2019

Sharvari Deshpande, Harishankar Nemani, Suresh Pothani, Khambata K, Anita Kumar, Prathap Kallamadi, N H Balasinor

Endocrinology. 160(1):220–234

Delineating the regulation of estrogen and androgen receptor expression by sex steroids during rat spermatogenesis.

2018

Kumar A, Khambata K, Deshpande-S, Raut S, Balasinor NH.

J Steroid Biochem Mol Biol. doi: 10.1016/j.jsbmb.2018.04.018, 2018

Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats

2017

Khambata Khushaan, Anita Kumar, Sharvari Deshpande, and N. H. Balasinor

Epigenetics. 12(11):953-963

Direct regulation of genes involved in sperm release by estrogen and androgen through their receptors and coregulators.

2017

Kumar A, Khambata K, Deshpande-S, Balasinor NH.,

J Steroid Biochem Mol Biol. 2017 Feb 27. pii: S0960-0760(17)30053-5. doi:10.1016/j.jsbmb.2017.02.017

Estrogen signaling, through estrogen receptor β, regulates DNA methylation and its machinery in male germ line in adult rats.

2017

Khambata K, Kumar A, Deshpande-S, Balasinor NH.,

Epigenetics. 2017 Mar 31:0. doi: 10.1080/15592294.2017.1309489.

Actin related protein complex subunit 1b controls sperm release, barrier integrity and cell division during adult rat spermatogenesis.

2016

Kumar A, Khambata K, Deshpande-S, Gaonkar R and Balasinor NH.

Biochimica et Biophysica Acta 1863:1996–2005, 2016.

Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis.

2016

Khambata K, Kumar A, Deshpande-S, Sonawane S, Balasinor NH.,

Molecular and Cellular Endocrinology 428: 89-100, 2016

Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation

2015

Kumar A, Khambata K, Gaonkar R, Sonawane S, Kadam L and Balasinor NH

Mol Cell Endocrinol 404: 91–101, 2015

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

2015

Khambata K, Kumar A, Kadam L, Balasinor NH

J Endocrinol 225:169-80, 2015

Aberrant methylation of multiple imprinted genes in embryos of tamoxifen-treated male rats

2013

Kedia-Mokashi NA, Kadam L, Ankolkar M, Khambata K, Balasinor NH

Reproduction 146:155-168, 2013

Proteomics in reproductive biology: Beacon for unraveling the molecular complexities

2013

Upadhyay RD, Balasinor NH, Kumar AV, Sachdeva G, Parte P, Khambata K

Biochim Biophys Acta Proteins and Proteomics 1834: 8–15, 2013

Name of Award	Awarding agency	Year
Dr (Mrs) Mridula Kamboj Young Scientist Award	Indian Society for the Study of Reproduction and Fertility	2018
European Society of Endocrinology Meeting Grant, European Society of Endocrinology Basic Science Meeting Grant, and Journal of Endocrinology Travel Grant	European Society of Endocrinology	2016
Awarded Lectureship (Life sciences) at the CSIR-National eligibility test (NET) examination	CSIR-UGC	2010

Project title	Funding agency	Year
Investigating sperm 5hmC landscape in male infertility and recurrent pregnancy loss	ICMR-NIRRCH	2022
Unravelling sperm epigenetic landscape regulated by estrogen receptors in adult male rats	ICMR-NIRRCH and SERB-Startup Research Grant	2020

Kushaan Khambata - ICMR-NIRRCH

Scientist C

Research Interests

Academic Background

Professional Experience

Awards & Achievements

Publications

Dopamine receptor D2 regulates genes involved in germ cell movement and sperm motility in rat test.

Molecular mechanisms underlying the effects of hypo- and hyper-prolactinemia on spermatogenesis and fertility in male rats

DNA methylation biomarkers to identify epigenetically abnormal spermatozoa in male partners from couples experiencing recurrent pregnancy loss.

Paternal obesity induces epigenetic aberrations and gene expression changes in placenta and fetus.

Immunoregulation in the testis and its implication in fertility and infections.

DNA methylation defects in spermatozoa of male partners from couples experiencing recurrent pregnancy loss.

Genome-wide identification of estrogen receptor binding sites reveals novel estrogen-responsive pathways in adult male germ cells.

Genetically Inherited Obesity and High-Fat Diet–Induced Obesity Differentially Alter Spermatogenesis in Adult Male Rats.

Delineating the regulation of estrogen and androgen receptor expression by sex steroids during rat spermatogenesis.

Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats

Direct regulation of genes involved in sperm release by estrogen and androgen through their receptors and coregulators.

Estrogen signaling, through estrogen receptor β, regulates DNA methylation and its machinery in male germ line in adult rats.

Actin related protein complex subunit 1b controls sperm release, barrier integrity and cell division during adult rat spermatogenesis.

Differential roles of estrogen receptors, ESR1 and ESR2, in adult rat spermatogenesis.

Estrogen and androgen regulate actin-remodeling and endocytosis-related genes during rat spermiation

Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats

Aberrant methylation of multiple imprinted genes in embryos of tamoxifen-treated male rats

Proteomics in reproductive biology: Beacon for unraveling the molecular complexities

Projects Ongoing