Director & Scientist G
Email: sachdevag[at]nirrch[dot]res[dot]in
Phone: + (91-22) 24192007
Department: Cell Physiology and Pathology
Research Interests
- Endometrial Functions and Dysfunctions
- Steroid Signaling in Prostate Cancers
Academic Background
| Degree | Academic institute | Year |
| MSc | Jawaharlal Nehru University, New Delhi | 1989 |
| PhD | Jawaharlal Nehru University, New Delhi | 1997 |
Professional Experience
| Post held | Institute/Organization | From | To |
| Scientist G and Director | Cell Physiology and Pathology Laboratory, National Institute for Research in Reproductive and Child Health, Mumbai | 2021 | Till date |
| Scientist F | Primate Biology Laboratory, National Institute for Research in Reproductive Health, Mumbai | 2017 | 2021 |
| Scientist E | Primate Biology Laboratory, National Institute for Research in Reproductive Health, Mumbai | 2012 | 2017 |
| Scientist D | Primate Biology Laboratory, National Institute for Research in Reproductive Health, Mumbai | 2007 | 2012 |
| Scientist C | Primate Biology Laboratory, National Institute for Research in Reproductive Health, Mumbai | 2002 | 2007 |
| Scientist B | Primate Biology Laboratory, National Institute for Research in Reproductive Health, Mumbai | 1997 | 2002 |
Present
| Name | Designation |
| Ms. Sushama Gadkar | Senior Technical Officer-2 |
| Mr. Balwant Mayekar | Laboratory Assistant |
| Rithika Rajendran | Ph.D. Scholar |
| Junita Desouza | Ph.D. Scholar |
| Ms Itti Munshi | Ph.D. Scholar |
| Mr Arif Hussain | Ph.D. Scholar |
| Ms Shashwati Nanda | Junior Research Fellow |
| Mr. Samir Kochar | Laboratory Attendant |
Past
| Name | Designation | From | To |
| Ruchi Kakkar | Ph.D. | 2014 | 2020 |
| Sheeba Jecob | Ph.D. | 2011 | 2017 |
| Sumit Bhutada | Ph.D. | 2008 | 2015 |
| Sonali Bhagwat | Ph.D. | 2009 | 2014 |
| Shruti Nimbkar | Ph.D. | 2006 | 2014 |
| Tanu Parmar | Ph.D. | 2003 | 2009 |
| Gracy Rosario | Ph.D. | 1999 | 2005 |
| Chirag Shah | Ph.D. | 1999 | 2005 |
Awards & Achievements
| Name of Award | Awarding Agency | Year |
| Young Scientist Award | Indian Society of Human Genetics | 1996 |
| Young Scientist Fellowship to attend the Silver Jubilee Celebrations of the Centre for Cellular and Molecular Biology (CCMB), Hyderabad | Cellular and Molecular Biology (CCMB) | 2002 |
| Long Term Biotechnology Overseas Associateship at National Cancer Institute, National Institutes of Health, USA from | Department of Biotechnology, Government of India | 2002-2003 |
| Awarded Swarn Kanta Dingley oration | ICMR, New Delhi | 2007 |
| Awarded 10th Royan International Research Award for the year 2009 | Royan International Twin Congress held at Tehran | 2009 |
| Awarded GP Talwar Midlevel Career Award | Indian Society for the Study in Reproduction and Society | 2010 |
| Awarded 16th Royan International Research Award for the year 2015 | International Twin Congress held at Tehran Iran | 2015 |
| Elected as a Fellow of the National Academy of Sciences, India | National Academy of Sciences, India | 2015 |
| Academic Editor of PLOS One | PLoS One | 2014-2018 |
| Awarded Short Term ICMR-DHR International Fellowship for Senior Biomedical Scientists | ICMR-DHR | 2019 |
| Editorial board member | Human Reproduction Update | 2023 |
Publications
The status of maternal syphilis in India: status quo?. Reviews and Research in Medical Microbiology ():10.1097/MRM.0000000000000416 October 02, 2024.
2024
Kuppusamy P, Sachdeva G, Gajbhiye RK, Nagarajan M.
Prevention and management of snakebite envenomation: Aqualitative study on perspectives and practices in Maharashtra and Odisha.
2024
Munshi H, Gavhande M, Bhad G, Mohanty B, Dash JP, Madavi K, Bansode M, Mohapatra A, Mahale SD, Pati S, Sachdeva G, Bawaskar HS, Gajbhiye RK.
Indian J Med Res. 2024.
https://doi.org/10.25259/ijmr_1566_23
The dynamics of SARS-CoV-2 infection in unvaccinated and vaccinated populations in Mumbai, India, between 28 December 2020 and 30 August 2021.
2023
Pregnancy outcomes among Indian women: increased prevalence of miscarriage and stillbirth during 2015-2021.
2023
Cytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report.
2023
Therapeutic metformin concentrations positively regulate proliferation in endometrial epithelial cells (EECs) via mTOR activation and augmented mitochondrial strength.
2023
Clinical presentation, pregnancy complications and outcomes of pregnant women with COVID-19 during the Omicron dominant third wave in Mumbai, India.
2022
Elevated risk of COVID-19 infection among people living with HIV in Mumbai – A retrospective study.
2022
Preparedness and strategies for addressing monkeypox infection in pregnant women in India.
2022
Estrogen receptor expression is modulated in human and mouse prostate epithelial cells during cancer progression
2022
Clinical characteristics and surgical management of endometriosis-associated infertility: A multicenter prospective cohort study.
2022
Dysregulation of X-ray repair cross-complementing 4 expression in the eutopic endometrium of women with endometriosis.
2022
Elevated Risk of COVID-19 Infection among People Living with HIV in Mumbai – A Retrospective Study. Re:GEN Open 2022
2022
Ketki Jawade, Priyanka Singh, Shahina Begum, Sharad Bhagat, Reshma Gaonkar, Shilpa Kerkar, Clara Aranha, Venkanna Bhanothu, Dimpu Gogoi, Karan Shah, Nupur Mukherjee, Kiran Munne, Shailesh Pande, Geetanjali Sachdeva, Smita D Mahale, Vikrant M Bhor, Dhanashree Jagtap, Vainav Patel
Plasma membrane proteome of adhesion-competent endometrial epithelial cells and its modulation by Rab11a.
2020
Endometrial DNA Damage Response is Modulated in Endometriosis
2020
Size, site, and signaling: Three attributes of estrogen receptors.
2019
Rab11a drives molecules to the surface of endometrial cells
2019
Estradiol: A Steroid with Multiple Facets.
2018
Investigation of HSA as a biocompatible coating material for arsenic trioxide nanoparticles.
2018
Use of ultrasound imaging for the diagnosis of abnormal uterine bleeding in the bonnet macaques (Macaca radiata)
2017
Cells with “Stemness”: Seeds for endometriosis?
2016
A triad of telomerase, androgen receptor and early growth response 1 in prostate cancer cells
2016
Use of ultrasound imaging for the diagnosis of abnormal uterine bleeding in the bonnet macaque (Macaca radiata)
2016
Secrets of Endometrial Receptivity: Some Are Hidden in Uterine Secretome
2016
Is testing of menstrual blood justifiable for diagnosis of endometrial Tuberculosis among infertile women?
2015
Proliferation and decidualization of endometrial stromal cells during embryo-attachment stage in bonnet monkeys (Macaca radiata)
2015
Arrays to detect Erring factors of Endometrial origin in Endometriosis
2015
Cell surfactomes of two endometrial epithelial cell lines that differ in their adhesiveness to embryonic cells
2014
Androgen receptor as a regulator of ZEB2 expression and its implications in epithelial-to-mesenchymal transition in prostate cancer
2014
Echography of the cervix and uterus during the proliferative and secretory phases of the menstrual cycle in bonnet monkeys (Macaca radiata)
2014
High mobility group box 1 (HMGB1) protein in human uterine fluid and its relevance in implantation
2014
Proteomics in reproductive biology: Beacon for unraveling the molecular complexities
2013
Endometrial polyps associated with endometrial hyperplasia in an obese bonnet monkey (Macaca radiata): a case report
2013
Uterine secretome and its modulation in rat (Rattus norvegicus)
2013
Endometrial receptivity: A revisit to functional genomics studies on human endometrium and creation of HGEx-ERdb
2013
Endometrial epithelial cell modifications in response to embryonic signals in bonnet monkeys (Macaca radiata)
2012
Long circulating PEGylated PLGA nanoparticles of cytarabine for targeting leukemia
2011
J Intracellular delivery of etoposide loaded biodegradable nanoparticles: cytotoxicity and cellular uptake studies
2011
Proteolytic tailoring of the heat shock protein 70 and its implications in the pathogenesis of endometriosis
2011
Spot’-ting differences between the eutopic and the ectopic endometrium of endometriosis patients
2010
Expression of Endometrial Protein Kinase A during Early Pregnancy in Bonnet Monkeys (Macaca radiata)
2009
Embryo-induced Alterations in the Molecular Phenotype of Primate Endometrium
2009
Differential expression of calreticulin, a reticuloplasmin in primate endometrium
2009
Protein profiling of human endometrial tissues in the mid- secretory and prodiferative phases of menstrual cycle
2009
Protein repertoire of human uterine fluid during the mid-secretory phase of the menstrual cycle
2008
N-terminal region of progesterone receptor B isoform in human spermatozoa
2005
Progesterone receptors: various forms and functions in reproductive tissues
2005
Ontogeny and cellular localization of SRY transcripts in the human testes and its detection in spermatozoa
2005
Rab Coupling Protein (RCP): a novel target of progesterone action in primate endometrium
2005
Morphological events in the primate endometrium in presence of a preimplantation embryo detected by the serum preimplantation factor bioassay
2005
Enhanced expressions of endometrial tumor necrosis factor alpha and its receptors during early pregnancy in bonnet monkeys
2005
Endometrial expression of immunomodulatory cytokines and their regulators during early pregnancy in bonnet monkeys (Macaca radiata)
2005
Characterization of a critical region in the hormone binding domain of sperm progesterone receptor
2005
Coexistence of intracellular and membrane-bound progress receptors in human testis
2005
Progesterone receptors in the testis: cellular and molecular characterization
2005
Progesterone receptors on human spermatozoa
2003
Role of progesterone in structural and biochemical remodeling of endometrium
2003
Effects of an antiprogestin on a pristone on the endometrium of bonnet monkeys: Morphometric and ultrastructural studies
2003
Progesterone receptor as an indicator of sperm function
2002
Expression profiles of endometrial leukemia inhibitory factor, transforming growth factor ?2 (TGF?2), and TGF?2 receptor in infertile bonnet monkeys
2001
Endometrial contraception: Modulation of molecular determinants of uterine receptivity
2000
Projects Ongoing
| Project title | Funding agency | From | To |
| Uterine Alarmins and their Relevance in Implantation | SERB | 2020 | 2023 |
| Eutopic endometrial cell repertoire in women presenting different subtypes of endometriosis and its association with endometrial receptivity | ICMR | 2023 | 2026 |
Projects Completed
| Project title | Funding agency | From | To |
| Molecular Determinants of Endometrial receptivity in Primates | Indo-US Department of Biotechnology | 2000 | 2003 |
| Endometrial Maps of Receptive and Nonreceptive Uterus in Primates | Indian Council of Medical Research | 2002 | 2005 |
| Structural and Molecular Signatures of Early Pregnancy on Primate Endometrium | Department of Science and Technology | 2004 | 2007 |
| Role of Cell Surface Molecules and their Trafficking in Endometrial Receptivity | Department of Biotechnology | 2006 | 2009 |
| An Inventory of Secreted Proteins and their Modified Forms in Human Uterine Fluid | Department of Biotechnology | 2007 | 2010 |
| Hormonal Regulation of Telomerase and its Possible Implications in Pathogenesis of Prostate Cancer | Department of Atomic Energy | 2008 | 2011 |
| Identification and Characterization of Membrane Bound Estrogen Receptors / Proteins on Prostate Cancer Cell Lines | Department of Atomic Energy | 2011 | 2014 |
| Pathways to the Oncogenesis in the Pathophysiology of Endometriosis | Department of Biotechnology | 2015 | 2018 |
| In Vitro and in Vivo Functional Significance of Cell Surface Estrogen Receptors in the Context of Prostate Cancer | Department of Atomic Energy | 2018 | 2021 |
| DNA Damage, Repair and Demethylation in the Pathogenesis of Endometriosis | Department of Biotechnology | 2019 | 2023 |