Dhanashree Jagtap - ICMR-NIRRCH

Scientist E

Email: jagtapd@nirrch.res.in
Phone: +(91-22) 24192014
Department: Cellular and Structural Biology

Research Interests

Structure-function studies on proteins
Protein-protein interactions

Academic Background

Degree	Academic institute	Year
Ph D (Life Sciences)	NIRRH (Mumbai University)	2012
PGDCR (Post Graduate Diploma in Clinical Research)	CREMA (Clinical Research Education & Management Academy), Mumbai	2009
M. Sc. (Biochemistry; Part Papers & Part Research)	NIRRH (Mumbai University)	1999
PGDMLT (Post Graduate Diploma in Medical Laboratory Technology)	Nirmala Niketan Polytechnic, Mumbai	1986
B. Sc. (Microbiology)	Guru Nanak Khalsa College (Mumbai University)	1985

Professional Experience

Post held	Institute/Organization	From	To
Scientist D	ICMR-NIRRCH	Sep 2020	Till date
Scientist C	ICMR-NIRRCH	Sep 2016	Aug 2020
Scientist B	ICMR-NIRRCH	May 2012	Aug 2016

Publications

Projects

Research Staff

Publications

Comparison of Anti-Trop2 Extracellular Domain Antibodies Generated Against Peptide and Protein Immunogens for Targeting Trop2-Positive Tumour Cells.

2023

Kamble PR, Kulkarni B, Malaviya A, Bajaj M, Breed AA, Jagtap D, Mahale S, Pathak BR.

Appl Biochem Biotechnol. 2023 Sep 1.

The dynamics of SARS-CoV-2 infection in unvaccinated and vaccinated populations in Mumbai, India, between 28 December 2020 and 30 August 2021.

2023

Bhanothu V, Munne K, Pande S, Singh P, Jagtap D, Aranha C, Gogoi D, Bhagat S, Gaonkar R, Kerkar S, Shah K, Mukherjee N, Bhor V, Patel V, Mahale SD, Sachdeva G, Begum S.

Arch Virol (ISSN No. 0304-8608), 2023; 168: 188-201.

FcγRIIIA affinity chromatography complements conventional functional characterization of rituximab.

2023

Narvekar A, Puranik A, Kulkarni B, Jagtap D, Jain R, Dandekar P.

Biotechnol Prog 39(1): e3304, 2023

Determinants of turn-around-time for early infant diagnosis of HIV testing: Retrospective analysis of national level PCR testing data.

2023

Gawde N, Kamble S, Kurle S, Jagtap D, Goel N, Nikhare K, Kamble S, Gade S, Verma V, Singh R, Nerurkar S, Rajan S, Das C.

Inquiry 60: 469580231159493, 2023

Elevated risk of COVID-19 infection among people living with HIV in Mumbai – A retrospective study.

2022

Jawade K, Singh P, Begum S, Bhagat S, Gaonkar R, Kerkar S, Aranha C, Bhanothu V, Gogoi D, Shah K, Mukherjee N, Munne K, Pande S, Sachdeva G, Mahale SD, Bhor VM, Jagtap D, Patel V

Re:GEN Open 2(1): 72-74, 2022

Determination of functional similarity of biosimilar H9P2S from an investigational CHO clone with Adalimumab

2022

Gupta K, Desai R, Jawade K, Jagtap DD, Modi D, Jain R, Dandekar P.

3 Biotech 12(11): 315, 2022

Loss to follow-up of HIV-exposed infants for confirmatory HIV test under Early Infant Diagnosis program in India: analysis of national-level data from reference laboratories

2022

Gawde N, Kamble S, Goel N, Nikhare K, Bembalkar S, Thorwat M, Jagtap D, Kurle S, Yadav N, Verma V, Kapoor N, Das C

BMC Pediatr 22(1): 602, 2022

Elevated Risk of COVID-19 Infection among People Living with HIV in Mumbai – A Retrospective Study. Re:GEN Open 2022

2022

Ketki Jawade, Priyanka Singh, Shahina Begum, Sharad Bhagat, Reshma Gaonkar, Shilpa Kerkar, Clara Aranha, Venkanna Bhanothu, Dimpu Gogoi, Karan Shah, Nupur Mukherjee, Kiran Munne, Shailesh Pande, Geetanjali Sachdeva, Smita D Mahale, Vikrant M Bhor, Dhanashree Jagtap, Vainav Patel

Re:GEN Open Volume 2, Number 1, 2022 DOI: 10.1089/regen.2022.0017

A novel ORF-1a based SARS- CoV- 2 RT-PCR assay to resolve inconclusive samples.

2021

Ketki Jawade, Akhauri Yash Sinha, Kiran Munne, Vikrant M Bhor, Smita D Mahale, Subhanjan Bhowmik, Dhanashree Jagtap, Vainav Patel.

International Journal of Infectious Diseases

A novel ORF1a-based SARS-CoV-2 RT- PCR assay to resolve inconclusive samples.

2021

Jawade K, Sinha AY, Bhagat S, Bhowmick S, Chauhan B, Kaginkar S, Palav H, Kasarpalkar N, Devadiga P, Karandikar K, Agrawal S, Shastri J, Munne K, Bhor VM, Mahale SD, Bhowmik S, Jagtap D, Patel V.

Int J Infect Dis. 2021 May;106:395-400.

sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 Infection.

2021

Jagtap D, Bhor VM, Bhowmick S, Kasarpalkar N, Sagvekar P, Kulkarni B, Pathak M, Chatterjee N, Dolas P, Palav H, Kaginkar S, Bhagat S, Munshi I, Parikh S, Agrawal S, Pawar C, Kaneria M, Mahale SD, Shastri J, Patel V.

Front Immunol. 2021 Jun 14;12:619906.

New insights of inhibins in ovarian physiology of fish.

2020

Ahmad I, Bhat IA, Jagtap DD, Selvaa Kumar C, Ferosekhan S, Afonso Luis OB.

Rev Fish Sci Aquac 28(2): 247-259, 2020.

Modelling and docking of Indian SARS-CoV-2 spike protein 1 with ACE2: implications for co-morbidity and therapeutic intervention.

2020

Jagtap D, C SK, Mahale S, Patel V.

arXiv:2004.06361; 14 Apr, 2020.

Thiol based mechanism internalises interacting partners to outer dense fibers in sperm.

2020

Kadam K, Khole VV, Ghosalkar K, Jagtap D, Yarramala DS, Ramachandran B.

Free Radic Biol Med 148: 170-181, 2020.

Computational and biological approach for studying structure-function of inhibin chimeric peptide antibodies in Clarias batrachus.

2019

Ahmad I, Bhat IA, Jagtap DD, Balasinor NH, Selvaa Kumar C, Chanu TI, Babitha Rani AM, Dar SA, Leya T, Gora AH, Saharan N.

Aquaculture. 2019 25 Feb: 501:153-160.

Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8

2019

Sutar J, Padwal V, Sonawani A, Nagar V, Patil P, Kulkarni B, Hingankar N, Deshpande-S, Idicula-Thomas S, Jagtap D, Bhattacharya J, Bandivdekar A, Patel V.

Virus Res. 2019 Nov;273:197763. doi: 10.1016/j.virusres.2019.197763.

Size, site, and signaling: Three attributes of estrogen receptors.

2019

Desouza J, Gadkar S, Jagtap D, Sachdeva G. Size,

Biomed Res J, 2019;6:37-48.

How the surface functionalized nanoparticles affect conformation and activity of proteins: Exploring through protein-nanoparticle interactions.

2019

Dyawanapelly S, Mehrotra P, Ghosh G, Jagtap DD, Dandekar P, Jain R.

Bioorg Chem. 2019 Feb;82:17-25.

Understanding the nano-bio interactions using real-time surface plasmon resonance tool.

2019

Atale SS, Dyawanapelly S, Jagtap DD, Jain R, Dandekar P.

Int J Biol Macromol. 2019 Feb 15;123:97-107.

Molecular characterization of inhibin-A: Structure and expression analysis in Clarias batrachus.

2018

Ahmad I, Jagtap DD, Selvaa Kumar C, Balasinor N, Babitha Rani AM, Agarwal D, Saharan N.

Gen Comp Endocrinol. 2018 Feb 10. pii: S0016-6480(17)30518-X. doi: 10.1016/j.ygcen.2018.02.007. [Epub ahead of print]

Inhibin anti-peptide antibody macromolecule: An approach to improve fecundity in Clarias batrachus.

2018

Ahmad I, Jagtap DD, Balasinor NH, Rani B, Bhat IA, Chadha NK, Rawat KD, Saharan N.

Int J Biol Macromol. 2018 Dec;120(Pt A):195-202.

Discordant HIV DNA PCR results among infants diagnosed with HIV infection and initiated on ART: a case series.

2017

Jagtap DD, Gawde NC, Kamble SV, Sharma AP, Paranjape RS.

Int J STD AIDS. 2017 Mar;28(4):415-417.

Assessing safety and protein interactions of surface-modified iron oxide nanoparticles for potential use in biomedical areas.

2017

Dyawanapelly S, Jagtap DD, Dandekar P, Ghosh G, Jain R.

Colloids Surf B Biointerfaces. 2017 Mar 29;154:408-420.

The rs10993994 in the proximal MSMB promoter region is a functional polymorphism in Asian Indian subjects

2015

Mhatre DR, Mahale SD, Khatkhatay MI, Achrekar SK, Desai SS, Jagtap DD, Dhabalia JV, Tongaonkar HB, Dandekar SP, Varadkar AM

Springerplus 4:380 (doi

Development of an ELISA for sPSP94 and utility of the sPSP94/sPSA ratio as a diagnostic indicator to differentiate between benign prostatic hyperplasia and prostate cancer

2014

Mhatre DR, Mahale SD, Khatkhatay MI, Desai SS, Jagtap DD, Dhabalia JV, Tongaonkar HB, Desai MP, Dandekar SP, Varadkar AM

Clin Chim Acta 436:256-62, 2014

Development of an ELISA for sPSP94 and utility of the sPSP94/sPSA ratio as a diagnostic indicator to differentiate between benign prostatic hyperplasia and prostate cancer

2014

Mhatre DR, Mahale SD, Khatkhatay MI, Desai SS, Jagtap DD, Dhabalia JV, Tongaonkar HB, Desai MP, Dandekar SP and Varadkar AM

Clin Chim Acta 436:256-262, 2014

Effect of FSH receptor binding inhibitor (FRBI-8) on FSH mediated granulosa cell signaling and proliferation

2013

Navalakhe R, Jagtap DD, Nayak S U, Nandedkar TD, Mahale SD

Chem Biol Drug Design 82:178-188, 2013

Prostate secretory protein of 94 amino acids (PSP94) binds to prostatic acid phosphatase (PAP) in human seminal plasma

2013

Ankleseria JH, Jagtap DD, Pathak BR, Kadam KM, Joseph S, Mahale SD

PLoS One 8:e58631, 2013

Is 37LRP cell surface receptor for PSP94?

2011

Pathak BR, Jagtap DD, Mahale SD

Asian J Androl 13:347, 2011

Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific

2010

Pathak BR, Breed AA, Nakhawa VH, Jagtap DD, Mahale SD

Asian J Androl 12: 677-689, 2010

Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer

2010

Kumar A, Jagtap DD, Mahale SD, Kumar M

J Mol Biol 397: 947-956, 2010

High affinity of seminal plasma PSP94 to human immunoglobulin is through the Fab domain

2010

Jagtap DD, Modi DN, Kumar M, Pathak BR, Mahale SD

Biochem Biophy Acta: Prot Proteom 1804: 1889-1894, 2010

Crystallization and preliminary x-ray differaction analysis of human seminal plasma protein PSP94

2009

Kumar M, Jagtap DD, Mahale SD, Prashar V, Kumar A, Das A, Bihani SC, Ferrer JL, Hosur MV, Ramanadham M

Acta Crystallogr Sect F Struct Biol Cryst 65, 2009

Interaction of FRBI-8: a novel protein from human ovarian follicular fluid, with FSH and its receptor

2009

Chitnis SS, Selvaakumar C, Jagtap DD, Barnwal RP, Chary KVR, Mahale SD and Nandedkar TD

Chem Biol Drug Des 73: 637-643, 2009

Disulphide bond reduction and S-carboxamidomethylation of PSP94 affects its conformation but not the ability to bind immunoglobulin

2007

Jagtap DD, Narahari A, Swamy MJ, Mahale SD

Biochim Biophys Acta 1774: 723-731, 2007

A Detailed study of the L2? long loop region of human chorionic gonadotrophin suggests it to be spirally close to, but not part of, the receptor-binding site

2002

Jagtap DD, Mahale SD, Mishra AK, Nandedkar TD and Iyer KS

J Endocrinol 172: 311-320, 2002

Human chorionic gonadotropin : An update on its receptor binding regions

2002

Iyer K S, Mishra A K, Mahale S D, and Jagtap D D.

Indian J Exp Biol 40: 448-455, 2002

Risk association of BST2 gene variants with disease progression in HIV-1 infected Indian cohort.

Gupte DS, Patil A, Selvaa Kumar C, Pandey S, Achrekar SK, Paranjape RS, Jagtap DD.

Infect Genet Evol 80: 104139, 2020 .

Name	Designation
Vanita Pachghare	Project Assistant

Project title	Funding agency	From	To
Delineating the role of human beta- microseminoprotein in male reproduction	ICMR	2023	2026

Dhanashree Jagtap - ICMR-NIRRCH

Scientist E

Research Interests

Academic Background

Professional Experience

Present

Publications

Comparison of Anti-Trop2 Extracellular Domain Antibodies Generated Against Peptide and Protein Immunogens for Targeting Trop2-Positive Tumour Cells.

The dynamics of SARS-CoV-2 infection in unvaccinated and vaccinated populations in Mumbai, India, between 28 December 2020 and 30 August 2021.

FcγRIIIA affinity chromatography complements conventional functional characterization of rituximab.

Determinants of turn-around-time for early infant diagnosis of HIV testing: Retrospective analysis of national level PCR testing data.

Elevated risk of COVID-19 infection among people living with HIV in Mumbai – A retrospective study.

Determination of functional similarity of biosimilar H9P2S from an investigational CHO clone with Adalimumab

Loss to follow-up of HIV-exposed infants for confirmatory HIV test under Early Infant Diagnosis program in India: analysis of national-level data from reference laboratories

Elevated Risk of COVID-19 Infection among People Living with HIV in Mumbai – A Retrospective Study. Re:GEN Open 2022

A novel ORF-1a based SARS- CoV- 2 RT-PCR assay to resolve inconclusive samples.

A novel ORF1a-based SARS-CoV-2 RT- PCR assay to resolve inconclusive samples.

sMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 Infection.

New insights of inhibins in ovarian physiology of fish.

Modelling and docking of Indian SARS-CoV-2 spike protein 1 with ACE2: implications for co-morbidity and therapeutic intervention.

Thiol based mechanism internalises interacting partners to outer dense fibers in sperm.

Computational and biological approach for studying structure-function of inhibin chimeric peptide antibodies in Clarias batrachus.

Effect of diversity in gp41 membrane proximal external region of primary HIV-1 Indian subtype C sequences on interaction with broadly neutralizing antibodies 4E10 and 10E8

Size, site, and signaling: Three attributes of estrogen receptors.

How the surface functionalized nanoparticles affect conformation and activity of proteins: Exploring through protein-nanoparticle interactions.

Understanding the nano-bio interactions using real-time surface plasmon resonance tool.

Molecular characterization of inhibin-A: Structure and expression analysis in Clarias batrachus.

Inhibin anti-peptide antibody macromolecule: An approach to improve fecundity in Clarias batrachus.

Discordant HIV DNA PCR results among infants diagnosed with HIV infection and initiated on ART: a case series.

Assessing safety and protein interactions of surface-modified iron oxide nanoparticles for potential use in biomedical areas.

The rs10993994 in the proximal MSMB promoter region is a functional polymorphism in Asian Indian subjects

Development of an ELISA for sPSP94 and utility of the sPSP94/sPSA ratio as a diagnostic indicator to differentiate between benign prostatic hyperplasia and prostate cancer

Development of an ELISA for sPSP94 and utility of the sPSP94/sPSA ratio as a diagnostic indicator to differentiate between benign prostatic hyperplasia and prostate cancer

Effect of FSH receptor binding inhibitor (FRBI-8) on FSH mediated granulosa cell signaling and proliferation

Prostate secretory protein of 94 amino acids (PSP94) binds to prostatic acid phosphatase (PAP) in human seminal plasma

Is 37LRP cell surface receptor for PSP94?

Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific

Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer

High affinity of seminal plasma PSP94 to human immunoglobulin is through the Fab domain

Crystallization and preliminary x-ray differaction analysis of human seminal plasma protein PSP94

Interaction of FRBI-8: a novel protein from human ovarian follicular fluid, with FSH and its receptor

Disulphide bond reduction and S-carboxamidomethylation of PSP94 affects its conformation but not the ability to bind immunoglobulin

A Detailed study of the L2? long loop region of human chorionic gonadotrophin suggests it to be spirally close to, but not part of, the receptor-binding site

Human chorionic gonadotropin : An update on its receptor binding regions

Risk association of BST2 gene variants with disease progression in HIV-1 infected Indian cohort.

Projects Ongoing

Projects Completed