Scientist G
Email: modid@nirrch.res.in
Phone: +(91-22) 2419-2034
Department: Molecular and Cellular Biology
Research Interests
- Understanding of mechanisms that drive embryo implantation and placental
development - Determining causes of implantation failure and pregnancy related disorders like
preterm birth and mother to child transmission of infections - Development of 3D organ-on-chip and organoid models of reproductive tissues
- Genetics of sexual development and infertility
Academic Background
| Degree | Academic institute | Year |
| Ph.D | BJ Wadia Hospital for Children | 2002 |
| M.Sc | Wilson College | 1995 |
| B.Sc | Wilson College | 1993 |
Professional Experience
| Designation | University/ Institution | From | To |
| Scientist F | ICMR-National Institute for Research in Reproductive and Child Health | Sept 2019 | till date |
| Scientist E | ICMR-National Institute for Research in Reproductive Health | Sept 2014 | Aug 2019 |
| Scientist D | ICMR-National Institute for Research in Reproductive Health | Sept 2010 | Aug 2014 |
| Visiting Fellow | Oulu University, Finland | March 2008 | June 2008 |
| Scientist C | ICMR-National Institute for Research in Reproductive Health | Sept 2006 | Aug 2010 |
| Scientist B | ICMR-National Institute for Research in Reproductive Health | May 2002 | Sept 2006 |
| Research Assistant | BJ Wadia Hospital For Children | March 1997 | Sept 2000 |
| Lecturer | Wilson College | June 1995 | Feb 1997 |
Present
| Name | Designation |
| Mrs. Sarika Ahire | Technical Officer |
| Mr. Sanjay Sakpal | Technician-B |
| Dr. Stacy Colaco | DHR Young Scientist Fellow |
| Dr. Jayeeta Giri | DBT/Wellcome Trust India Alliance Early Career fellow |
| Mrs. Anuradha Mishra | ICMR SRF |
| Mrs. Nancy Ashary | ICMR SRF |
| Mrs. Richa Sharma | PhD student |
| Mr. Anshul Bhide | PhD student |
| Ms. Babita Negi | PhD student |
| Ms. Pranya N | PhD student |
Past
| Name | Designation | From | To |
| Dr. Geeta Godbole | PhD student | 2004 | 2008 |
| Dr. Vrushali Sagare-Patil | PhD student | 2005 | 2009 |
| Dr. Sanjukta Sen | PhD student | 2007 | 2014 |
Awards & Achievements
| Name of Award | Awarding agency | Year |
| FNASc | National Academy of Sciences India | 2020 |
| PM Bhargava Oration award | Academy of Clinical Embryologists | 2017 |
| GP Talwar Middle Career Scientist Award | Indian Society for the Study of Reproduction & Fertility. | 2017 |
| ICMR-Tilak Venkoba Rao Award | Indian Council of Medical Research, Govt of India | 2010 |
| GP Talwar Young Scientist Award | Indian Society for the Study of Reproduction & Fertility | 2009 |
| Innovative Young Biotechnologist Award 2007 | Department of Biotechnology, Govt of India | 2007 |
| Young Scientist Platinum Jubilee Award | National Academy of Sciences India (NASI) | 2007 |
| Young Scientist Medal | Indian National Science Academy (INSA) | 2006 |
Publications
Placental exosomes in pregnancy and preeclampsia.
2025
Nishi K, Modi D
Am J Reprod Immunol. 2024 May;91(5):e13857.PMID: 38716824.
https://doi.org/10.1111/aji.13857
Targeting molecular cross-talk between tumor cells and tumor associated macrophage as therapeutic strategy in triple negative breast cancer.
2023
LHX2 in germ cells control tubular organization in the developing mouse testis.
2023
Immune alterations in recurrent implantation failure.
2023
Special issue: Clinical reproductive immunology: Indian perspective.
2023
Determination of functional similarity of biosimilar H9P2S from an investigational CHO clone with Adalimumab
2022
Association of AMH and AMHR2 gene polymorphisms with ovarian response and pregnancy outcomes in Indian women
2022
Protocol for a prospective, hospital-based registry of pregnant women with SARS-CoV-2 infection in India: PregCovid Registry study.
2022
Clinical profile of SARS-CoV-2-infected neonates.
2022
Mechanisms of group B Streptococcus-mediated preterm birth: lessons learnt from animal models.
2022
Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer.
2022
#ESHREjc report: renewing the old: novel stem cell research for unsolved ART problems.
2022
False-positive detection of Group B Streptococcus (GBS) in chromogenic media (Strep B Carrot Broth) due to presence of Enterococcus faecalis in High Vaginal swabs.
2022
Mitochondrial DNA levels in trophectodermal cells show no association with blastocyst development and pregnancy outcomes
2022
Lhx2 in germ cells suppresses endothelial cell migration in the developing ovary.
2022
Outcomes of COVID-19 in pregnant women with sickle cell disease in India: A case series.
2022
Differential impact of COVID-19 in pregnant women from high-income countries and low- to middle-income countries: A systematic review and meta-analysis.
2021
Clinical characteristics, outcomes, & mortality in pregnant women with COVID-19 in Maharashtra, India: Results from PregCovid registry.
2021
Central residues of FSHβ (89-97) peptide are not critical for FSHR binding: Implications for peptidomimetic design
2021
Clinical Characteristics, Management, and Short-Term Outcome of Neonates Born to Mothers with COVID-19 in a Tertiary Care Hospital in India.
2021
Clinical Presentation of Cases with SARS-CoV-2 Reinfection/Reactivation.
2021
Immunoregulation in the testis and its implication in fertility and infections.
2021
Impact of severe acute respiratory syndrome coronavirus-2 on multiple gestation pregnancy
2020
Clinical presentations, pregnancy complications, maternal outcomes in pregnant women with COVID-19 and tuberculosis: A retrospective cohort study
2020
Persistence of SARS-CoV-2 in the first trimester placenta leading to vertical transmission and fetal demise from an asymptomatic mother
2020
Universal screening identifies asymptomatic carriers of SARS-CoV-2 among pregnant women in India
2020
Co-infection of Malaria and Dengue in Pregnant women with SARS-CoV-2.
2020
Identification and in vivo validation of a 9-mer peptide derived from FSHβ with FSHR antagonist activity
2020
In vivo studies of 3D starch–gelatin scaffolds for full-thickness wound healing.
2020
Homeobox genes in endometrium: From development to decidualization.
2020
Single-cell RNA-seq identifies cell subsets in human placenta that highly expresses factors driving pathogenesis of SARS-CoV-2.
2020
The 2019 PGDIS position statement on transfer of mosaic embryos within a context of new information on PGT-A.
2020
Resuming assisted reproduction services during COVID-19 pandemic: An initial Indian experience.
2020
Spatial and temporal changes in the expression of steroid hormone receptors in mouse model of endometriosis
2020
Mouse model for endometriosis is characterized by proliferation and inflammation but not epithelial-to-mesenchymal transition and fibrosis.
2020
Genetics of the human Y chromosome and its association with male infertility
2018
Simplified approach for in-vitro production and purification of cell derived Cancer Antigen 15-3
2018
Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion
2017
Progesterone requires heat shock protein 90 (HSP90) in human sperm to regulate motility and acrosome reaction
2017
Extra-oviductal expression of oviductal glycoprotein 1 in mouse: Detection in testis, epididymis and ovary
2017
Assessment of oxidative stress in serum of pulmonary tuberculosis patients
2017
Role of Y Chromosome Microdeletions in Clinical Evaluation of Infertile Males
2017
Levels of microRNA miR-16 and miR-155 are altered in serum of patients with tuberculosis and associate with responses to therapy
2017
Identification of motility-associated progesterone-responsive differentially phosphorylated proteins
2017
Estrogen is essential but not sufficient to induce endometriosis
2017
Histochemical Staining of Collagen and Identification of Its Subtypes by Picrosirius Red Dye in Mouse Reproductive Tissues
2017
Membrane vesicles of group B streptococcus disrupt feto-maternal barrier leading to preterm birth.
2016
Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia.
2016
Decidual control of trophoblast invasion.
2016
Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions
2015
56 Cellular ontogeny of RBMY during human spermatogenesis and its role in sperm motility
2013
HIV gp120 induced gene expression signatures in vaginal epithelial cells
2013
Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction
2013
Y chromosome microdeletions in infertile men: prevalence, phenotypes and screening markers for the Indian population
2013
AP-1 transcription factors, mucin-type molecules and MMPs regulate the IL-11 mediated invasiveness of JEG-3 and HTR-8/SVneo trophoblastic cells
2012
Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa
2012
Endometrial biology during trophoblast invasion
2012
Decidualized endometrial stromal cell derived factors promote trophoblast invasion
2011
HIV gp 120 Binds to Mannose Receptor on Vaginal Epithelial cells and Induces Production of Matrix Metalloproteinases
2011
High affinity of seminal plasma PSP94 to human immunoglobulin is through the Fab domain
2010
Follicle stimulating hormone receptor gene variants in women with primary and secondary amenorhea
2010
Expression of Endometrial Protein Kinase A during Early Pregnancy in Bonnet Monkeys (Macaca radiata)
2009
Follicle-stimulating hormone receptor polymorphism (Thr307 Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women
2009
Poor ovarian response to gonadotropin stimulation is associated with FSH receptor polymorphism
2009
Stage – specific localization and expression of c-kit in the adult human testis
2009
Gene expression profiling during early folliculogenesis in the mouse ovary
2009
Stage-specific localization and expression of c-kit in the adult human testis
2009
Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure
2009
Identification of genes regulated by an interaction between ?v?3 integrin and vitronectin in murine deciduas
2008
Altered expression of progesterone receptors in testis of infertile man
2008
Exposure of adult rats to estradiol valerate induces ovarian cyst with early senescence of follicles
2007
Regulation of homeobox A10 expression in the primate endom etrium by progesterone and embryonic stimuli
2007
Screening for FOXL2 gene mutations in women with premature ovarian failure: an Indian experience
2007
Differential gene expression in transition of primordial to preantral follicles in mouse ovary
2006
Developmental expression and cellular distribution of Mullerian inhibiting substance in the primate ovary
2006
N-terminal region of progesterone receptor B isoform in human spermatozoa
2005
Progesterone receptors in the testis: cellular and molecular characterization
2005
Coexistence of intracellular and membrane-bound progress receptors in human testis
2005
Endometrial expression of immunomodulatory cytokines and their regulators during early pregnancy in bonnet monkeys (Macaca radiata)
2005
Morphological events in the primate endometrium in presence of a preimplantation embryo detected by the serum preimplantation factor bioassay
2005
Rab Coupling Protein (RCP): a novel target of progesterone action in primate endometrium
2005
Ontogeny and cellular localization of SRY transcripts in the human testes and its detection in spermatozoa
2005
Down syndrome: a study of chromosomal mosaicism
2003
In vitro effects of aspirin and salicylate on erythrocytes:size and+/K+ Atpase activity
2003
Progesterone receptors on human spermatozoa
2003
Projects Ongoing
| S. No. | Project title | Funding agency | From | To |
| 1. | Deciphering the immnunomodulatory roles of Homeobox A10 in the endometrium during embryo implantation | DBT | 2021 | 2024 |
| 2. | Development of a Microfluidic-Based Tool for Assessing Placental Functions and Evaluating Its Potential Application in Pregnancy-Related Disorders | Intramural | 2023 | 2027 |
| 3. | Determining the role of HOXA10 in the pathogenesis of endometriosis | Intramural | 2023 | 2025 |
| 4. | Investigating the role of epithelial to mesenchymal transition in the process of embryo implantation | Intramural | 2023 | 2026 |
| 5. | Study on placenta of women with coronavirus disease 2019 (COVID-19) and its correlation with pregnancy and neonatal outcomes | Intramural | 2023 | 2025 |
Projects Completed
| S No. | Project Title | Funding Agency | From | To |
| 1 | Investigating the role of epithelial to mesenchymal transition in the process of embryo implantation | DST-SERB | 2019 | 2022 |
| 2 | Development of a microfluidic based tool for assessing placental functions and evaluating its potential application in pregnancy related disorders | DST-IMPRINT II-C | 2019 | 2022 |
| 3 | Deciphering the roles of Lhx2 in mammalian gonad development | DBT | 2015 | 2018 |
| 4 | Determining role of HoxA 10 in endometrial physiology & pathogenesis of endometriosis | DST-SERB | 2014 | 2018 |
| 5 | To develop a rapid PCR kit for detection of common infections associated with preterm and still birth | ICMR-Medical Innovation | 2019 | 2021 |
| 6 | Development and Validation of a PCR based technology for detection of Yq microdeletions in diagnosis of male infertility. | ICMR-PDF | 2016 | 2019 |