About Us
With an aim to generate cellular models for neuro-developmental and neuro-psychiatric disorders, the Stem Cell Biology lab has embarked onto the area of “induced Pluripotent Stem Cell (iPSC)”. Under this initiative, we have successfully generated iPSCs from patients carrying various microdeletions and differentiated these into cortical neurons. Two control iPSCs lines have been generated which can be shared with investigators for research.
The department had previously derived two well characterized human embryonic stem cells lines, KIND1 and KIND2. These cell lines have been successfully used for various research projects to differentiate into various lineages. This embryonic stem cells have been used in-house to differentiate into pancreatic progenitor and cardiac progenitors. These two cell lines have been shared with many researchers in the past across India for research.
Considering the relevance of pregnancy related complications and lack of an in-vitro model to study the same, department has undertaken a study to use hESCs to differentiate into trophectoderm lineage. We have shown the expression of CDX2, GATA3, TFAP2A, TFAP2C, CGA and CGB in the differentiated cells which demonstrates lineage specific differentiation.
The department has expanded its horizon onto the area of adult tissue-resident stem cells. Studies were initiated to explore the role of various endometrial stem cells (epithelial progenitor, mesenchymal stem cells and side population) in the development of Endometriosis. Through animal experiments, we have demonstrated the formation of endometriosis-like lesion following transplantation of endometrial stem cells into the kidney capsule.
People
| Name | Designation |
| Dr Dhanjit Kumar Das | Scientist E & Head |
| Mrs Vaishali Bhogate | Sr. Technical Officer-1 |
| Dr Shyla R Menon | Technical Officer C |
| Dr Sandhya Anand | Technical Officer B |
| Mr Shivaji Gondhali | Laboratory Assistant |
Projects
Projects (Ongoing):
| Title | Funding Agency |
| Human Endometrial Stem Cells and their Possible role in the Etiology of Endometriosis | Department of Biotechnology (DBT) |
| Omics of Serum Exosomes in Endometriosis: An Attempt to identify a possible Biomarker | Indian Council of Medical Research (ICMR) |
| Omics of placental exosomes in early onset preeclampsia: an approach towards identifying predictive biomarkers | Department of Biotechnology (DBT) |
Projects (Completed):
| Title | Funding Agency | From | To |
| Functional study of Voltage-gated Calcium Channel gene mutations in Schizophrenia using induced Pluripotent Stem Cells (iPSCs): Anew approach for developing a cellular model | Science & Engineering Research Board (DST-SERB) | 2017 | 2021 |
| Genetic Characterization of Mitochondrial oxidative phosphorylation (OXPHOS) disorders for development of a non-invasive diagnostic tool in children | ICMR – Medical Innovation Fund | 2019 | 2022 |
| Prevalence of Fragile X syndrome and its neuropsychological correlates among children with development delay attending OPD services of Assam Medical College & Hospitals, Dibrugarh | Department of Biotechnology (DBT) | 2019 | 2022 |
| Mutational analysis of MECP2 and CDKL5 gene in Indian cases of Rett Syndrome (RTT) | Science & Engineering Research Board (DST-SERB) | 2011 | 2015 |
Contact Us
Telephone: +(91-22)24192124
Email Id: stemcell[at]nirrch[dot]res[dot]in
| Name | Designation | Email Id | Phone no |
| Dr Dhanjit K Das | Scientist E | dasd[at]nirrch[dot]res[dot]in | +(91-22)24192012 |