About Us
A major goal of the research pursued at the Cell Physiology and Pathology Laboratory (previously known as Primate Biology Laboratory) is to decipher the cellular and molecular basis of uterine functions, endometrial receptivity, endometrial repair breakdown and dysfunctions (endometriosis, fibroids) recurrent implementation failure. We also interested in identifying the phenotypes of gestational diabetes in Indian population. In addition, we are pursuing studies to elucidate the role of steroid signaling in pathogenesis of prostate cancer. It is anticipated that this descriptive research will pave way for the discovery of the key molecules / pathways of relevance in reproductive functions / dysfunctions in women and prostate cancer in men.
Our previous studies led to the identification of several progesterone-dependent targets of relevance in endometrial receptivity in implantation-incompetent bonnet monkeys (Macaca radiata) model. We also succeeded in developing a primate model for very early pregnancy that enable us to identify cell-type specific changes in the endometrium during embryo apposition and attachment. Further we developed a database of the receptivity-associated genes and an inventory of secreted proteins in uterine fluid in humans, valuable resources for those engaged in endometrial biology research. We further demonstrated the functional relevance of secreted proteins in endometrial receptivity. Our investigations unraveled the mechanisms involved in endowing the endometrial epithelial cells with adhesiveness. Currently we are engaged in investigating DNA damage and DNA repair in the pathogenesis of endometriosis. The role of damage associated molecular pattern (alarmins) being investigated in recurrent implementation failure and pathologies caused by impaired endometrial breakdown and repair.
Our group is also interested in elucidating the mechanisms underlying conventional and nonconventional steroid signaling in prostate cancer pathogenesis. These investigations have revealed the role of genomic and non-genomic androgen and estrogen signaling in epithelial-to-mesenchymal transition in prostate cancer.
People
| Name | Designation |
| Dr. Geetanjali Sachdeva | Scientist G / Director |
| Dr. Uddhav Chaudhari | Scientist E |
| Dr. Nupur Mukherjee | Scientist C |
| Ms Sushama Gadkar | Sr. Technical Officer-2 |
| M. Imran | Ph.D. Scholar |
| Rithika Rajendran | Ph.D. Scholar |
| Junita Desouza | Ph.D. Scholar |
| Aditya Khandvilkar | Ph.D. Scholar |
| Ms Itti Munshi | Ph.D. Scholar |
| Mr Golden Paswan | Ph.D. Scholar |
| Mr Arif Hussain | Ph.D. Scholar |
| Ms Shashwati Nanda | Junior Research Fellow |
| Balwant Mayekar | Laboratory Assistant |
| Mr. Mahesh Dhuri | Laboratory Assistant |
Projects
Projects (Ongoing)
| Title | Funding Agency | From | To |
| Eutopic endometrial cell repertoire in women presenting different subtypes of endometriosis and its association with endometrial receptivity | ICMR-Adhoc | 2022 | 2025 |
| Uterine Alarmins and their Relevance in Implantation | SERB, DST | 2020 | 2023 |
Projects (Completed projects in last 10 years)
| Title | Funding Agency | From | To |
| Hormonal Regulation of Telomerase and its Possible Implications in Pathogenesis of Prostate Cancer | Department of Atomic Energy | 2008 | 2011 |
| Identification and Characterization of Membrane Bound Estrogen Receptors / Proteins on Prostate Cancer Cell Lines | Department of Atomic Energy | 2011 | 2014 |
| Development of a non-human primate model for endometrial hyperplasia | Science and Engineering Research Board | 2012 | 2015 |
| Effect of metformin on hormonal, metabolic and endometrial profile in obese bonnet monkeys (Macaca Radiata) | Science and Engineering Research Board | 2013 | 2017 |
| Pathway to oncogenesis in the pathophysiology of endometriosis | Department of Biotechnology (DBT) | 2015 | 2018 |
| In vitro and in vivo functions of cell surface estrogen receptors in the context of prostate cancer | Department of atomic Energy (DAE) | 2018 | 2021 |
| Role of RAGE and HMGB1 in endometrial repair | Department of Science and technology (DST) | 2019 | 2022 |
| Investigating the contribution of DNA damage, repair and demethylation in pathogenesis of endometriosis | Department of Biotechnology (DBT) | 2019 | 2022 |
Contact Us
Telephone: +(91-22)24192111
Email Id: cpp[at]nirrch[dot]res[dot]in
| Name | Designation | Email Id | Phone no |
| Dr. Geetanjali Sachdeva | Head of Department; Scientist G | sachdevag[at]nirrch[dot]res[dot]in | +(91-22)24192007 |
| Dr. Uddhav Chaudhari | Scientist E | chaudhariu[at]nirrch[dot]res[dot]in | +(91-22)24192008 |